We've, of course, seen this very early on in molecular biology when the structure of DNA was solved, and immediately became clear why it was the basis for heredity. I think may of you are probably familiar with this quote, that "nothing in biology makes sense except in the light of evolution." And I'd like to offer a modified version of that, which is little in biology make sense except in light of structure, protein structure, DNA structure. As you've seen in the syllabus, the first couple of lectures are really a detailed look at protein structure, molecular level analysis, and then we'll move into some of these other levels of higher order, including protein DNA interactions and gene regulatory networks. So we've got a lot of ground to cover, but I think we'll be able do it. This unit is going to focus on moving across scales in computational biology, looking from computational issues that deal with the fundamentals of protein structure at the atomic level to the level of protein-protein interactions between pairs of molecules, protein DNA interactions and small molecules, and then ultimately into protein network. It's a somewhat impersonal setting with the video cameras and the amphitheater, but hopefully we can overcome that. And also, please, during class, ask questions.
I'd like to encourage you to contact me outside of class if you have any questions, if you want to meet. To make a donation or view additional materials from hundreds of MIT courses, visit MIT OpenCourseWare at. Your support will help MIT OpenCourseWare continue to offer high quality educational resources for free. The following content is provided under a Creative Commons license.
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